Browsing Experimentally Confirmed database

Result: Your query found 3 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farR
  • BacMet ID: BAC0505
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae, Neisseria meningitidis serogroup B (strain MC58)
  • Location: Chromosome
  • Compound: Palmitic acid [class: Free Fatty Acids]
  • Description: FarR negatively controls expression of farAB by directly binding to the farAB promoter. MtrR binds to the farR promoter, thereby repressing farR expression. MtrR regulates farAB in a positive fashion by modulating farR expression.
  • Length (amino acid): 146
  • Reference: Lee et al. 2003; Pubmed- 14645274

    		• Similar resistance genes in 'BacMet Predicted database'
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